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A multicenter, randomized, open-label Phase 1/2 neoadjuvant clinical trial of EGL-001 in patients with head and neck squamous cell carcinoma (HNSCC)

Trial Profile

A multicenter, randomized, open-label Phase 1/2 neoadjuvant clinical trial of EGL-001 in patients with head and neck squamous cell carcinoma (HNSCC)

Status: Planning
Phase of Trial: Phase I/II

Latest Information Update: 11 Mar 2026

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At a glance

  • Drugs EGL 001 (Primary) ; Pembrolizumab (Primary)
  • Indications Head and neck cancer; Squamous cell cancer
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 11 Mar 2026 New trial record
  • 02 Mar 2026 According to Egle Therapeutics media release, company announced that it was awarded approximately 8 million in grant funding by Horizon Europe, the European Commissions key funding program for research and innovation. This funding from the European Union will support an Egle-led initiative in partnership with a consortium of four leading European scientific institutions to advance the clinical development of EGL-001.
  • 02 Mar 2026 According to Egle Therapeutics media release, company will collaborate with University College London (United Kingdom), Vall dHebron Institute of Oncology (VHIO) (Spain), Gustave Roussy (France), and Technical University of Dresden (Germany) to conduct this trial.

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