Trial Profile

A Phase 1, First-in-Human, Biomarker-Guided, Dose-Escalation and Expansion Study of Locoregional Dual-Targeting CAR-NK Cells Directed Against IL13Rα2, EGFR/EGFRvIII, and/or B7-H3 (CD276) in Adults With Recurrent or Progressive Glioblastoma or High-Grade Glioma

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 24 Mar 2026

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At a glance

Drugs Dual-IL13Ra2A/EGFR-targeting-CAR-NK-cell-therapy-Beijing-Biotech (Primary) ; Cyclophosphamide; Fludarabine
Indications Glioblastoma; Glioma
Focus Adverse reactions; First in man
Acronyms DUAL-CAR-NK-GB
Sponsors Beijing BioTech

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