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TACE or Ablation Combined With Sintilimab and Ipilimumab N01 as Neoadjuvant Therapy for Resectable Hepatocellular Carcinoma With Intermediate-High Recurrence Risk: A Multicenter, Multigroup, Randomized, Phase ??? Exploratory Clinical Trial

Trial Profile

TACE or Ablation Combined With Sintilimab and Ipilimumab N01 as Neoadjuvant Therapy for Resectable Hepatocellular Carcinoma With Intermediate-High Recurrence Risk: A Multicenter, Multigroup, Randomized, Phase ??? Exploratory Clinical Trial

Status: Not yet recruiting
Phase of Trial: Phase II

Latest Information Update: 11 Apr 2026

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At a glance

  • Drugs Ipilimumab (Primary) ; Lenvatinib (Primary) ; Sintilimab (Primary)
  • Indications Liver cancer
  • Focus Therapeutic Use
  • Acronyms ACTION-001

Most Recent Events

  • 30 Mar 2026 New trial record
  • 27 Mar 2026 Number of treatment arms are increased from 4 to 5 by the addition of "No Intervention: Surgery alone". Planned enrollment is also increased.
  • 27 Mar 2026 Planned number of patients changed from 90 to 105.

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