Trial Profile

A phase 2 study of GPV-381 in advanced periodontitis.

Status: Planning

Phase of Trial: Phase II

Latest Information Update: 01 Apr 2026

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At a glance

01 Apr 2026 New trial record
24 Mar 2026 According to Denteric media release, The planned Phase 2 study is expected to evaluate safety, immunogenicity, and key clinical endpoints in patients with advanced periodontitis, including measures of periodontal pocket depth, tissue healing, and progression of bone loss. The study will also assess local and systemic inflammatory biomarkers to further characterize the impact of gingipain inhibition on disease biology.
24 Mar 2026 According to Denteric media release, company announced that the U.S. Food and Drug Administration (FDA) has cleared the Investigational New Drug (IND) application for GPV381

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