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A Phase 2 trial investigating the benefit of the bezuclastinib plus sunitinib combination for first-line GIST patients with exon 9 mutations who are naive to, or recently initiated treatment with, imatinib.

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Trial Profile

A Phase 2 trial investigating the benefit of the bezuclastinib plus sunitinib combination for first-line GIST patients with exon 9 mutations who are naive to, or recently initiated treatment with, imatinib.

Status: Planning
Phase of Trial: Phase II

Latest Information Update: 18 May 2026

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At a glance

  • Drugs Bezuclastinib (Primary) ; Sunitinib (Primary)
  • Indications Gastrointestinal stromal tumours
  • Focus Therapeutic Use

Most Recent Events

  • 05 May 2026 According to a Cogent Biosciences media release, company plans to initiate the trial in first half of 2026.
  • 14 Apr 2026 New trial record
  • 01 Apr 2026 According to a Cogent Biosciences media release, company is on track this quarter to initiate a Phase 2 trial investigating the benefit of the bezuclastinib plus sunitinib combination for first-line GIST patients with exon 9 mutations who are naive to, or recently initiated treatment with, imatinib.

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