Trial Profile

A Phase 1/1b Open-Label, Multicenter, First-in-Human Study Evaluating Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of RGT-490 as a Single Agent in Adult Subjects With Locally Advanced or Metastatic PIK3CA-Mutated Solid Tumors Including HR+/HER2- Breast Cancers

Status: Not yet recruiting

Phase of Trial: Phase I

Latest Information Update: 29 Apr 2026

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At a glance

Drugs RGT 490 (Primary)
Indications Advanced breast cancer; Cervical cancer; Endometrial cancer; HER2 negative breast cancer; Ovarian cancer
Focus First in man; Therapeutic Use
Sponsors Regor Therapeutics

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