An Open-Label Study to Determine the Safety and Efficacy of INCB018424 in Patients With Advanced Polycythemia Vera or Essential Thrombocythemia Refractory to Hydroxyurea

Trial Profile

An Open-Label Study to Determine the Safety and Efficacy of INCB018424 in Patients With Advanced Polycythemia Vera or Essential Thrombocythemia Refractory to Hydroxyurea

Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 12 Aug 2017

At a glance

  • Drugs Ruxolitinib (Primary)
  • Indications Essential thrombocythaemia; Polycythaemia vera
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Incyte Corporation
  • Most Recent Events

    • 12 Aug 2017 Results (n=39, data cutoff: 22 Feb 2016) assessing the long-term efficacy and safety of ruxolitinib treatment in the essential thrombocythemia cohort, published in the Blood Journal.
    • 14 Jun 2015 Pooled safety analysis (NCT00726232, RELIEF and RESPONSE) results presented at the 20th Congress of the European Haematology Association.
    • 02 Jun 2015 Pooled safety analysis (This study, RELIEF and RESPONSE) results presented at the 51st Annual Meeting of the American Society of Clinical Oncology.
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