A Randomized, Double-Blind, Phase 3 Study of the Janus Kinase (JAK) 1/2 Inhibitor, Ruxolitinib, or Placebo in Combination With Capecitabine in Subjects With Advanced or Metastatic Adenocarcinoma of the Pancreas Who Have Failed or Are Intolerant to First-Line Chemotherapy (The JANUS 1 Study)

Trial Profile

A Randomized, Double-Blind, Phase 3 Study of the Janus Kinase (JAK) 1/2 Inhibitor, Ruxolitinib, or Placebo in Combination With Capecitabine in Subjects With Advanced or Metastatic Adenocarcinoma of the Pancreas Who Have Failed or Are Intolerant to First-Line Chemotherapy (The JANUS 1 Study)

Discontinued
Phase of Trial: Phase III

Latest Information Update: 13 Jul 2017

At a glance

  • Drugs Ruxolitinib (Primary) ; Capecitabine
  • Indications Adenocarcinoma; Pancreatic cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms JANUS 1
  • Sponsors Incyte Corporation
  • Most Recent Events

    • 27 Jan 2017 This trial has been completed in Spain (end date: 12 Dec 2016).
    • 21 Jan 2017 Results assessing the efficacy and safety from JANUS 1 and JANUS 2 studies, presented at the 2017 Gastrointestinal Cancers Symposium.
    • 06 Mar 2016 Planned End Date changed from 1 Apr 2016 to 1 Aug 2016 as reported by ClinicalTrials.gov record.
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