A Phase II Basket Study of the Oral TRK Inhibitor LOXO-101 (Larotrectinib) in Subjects With NTRK Fusion-Positive Tumors

Trial Profile

A Phase II Basket Study of the Oral TRK Inhibitor LOXO-101 (Larotrectinib) in Subjects With NTRK Fusion-Positive Tumors

Recruiting
Phase of Trial: Phase II

Latest Information Update: 11 Jul 2017

At a glance

  • Drugs Larotrectinib (Primary)
  • Indications Biliary cancer; CNS cancer; Colorectal cancer; Non-small cell lung cancer; Salivary gland cancer; Sarcoma; Solid tumours; Thyroid cancer
  • Focus Therapeutic Use
  • Acronyms NAVIGATE
  • Sponsors Loxo Oncology
  • Most Recent Events

    • 06 Jun 2017 Results (data cut off: 31 Jan 2017, n=55) from NCT02122913, NCT02637687 and NCT02576431 studies, presented at the 53rd Annual Meeting of the American Society of Clinical Oncology.
    • 03 Jun 2017 Combined interim data from this and two other trials was presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2017, according to a Loxo Oncology media release.
    • 03 Jun 2017 Combined interim data from this and two other trials published in a Loxo Oncology media release.
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