A Randomized, Double-blind Phase 3 Study of Vadastuximab Talirine (SGN-CD33A) Versus Placebo in Combination With Azacitidine or Decitabine in the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)

Trial Profile

A Randomized, Double-blind Phase 3 Study of Vadastuximab Talirine (SGN-CD33A) Versus Placebo in Combination With Azacitidine or Decitabine in the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)

Discontinued
Phase of Trial: Phase III

Latest Information Update: 14 Aug 2017

At a glance

  • Drugs Vadastuximab talirine (Primary) ; Azacitidine; Decitabine
  • Indications Acute myeloid leukaemia
  • Focus Registrational; Therapeutic Use
  • Acronyms CASCADE
  • Sponsors Seattle Genetics
  • Most Recent Events

    • 19 Jun 2017 According to a company media release, Seattle Genetics is discontinuing this trial following consultation with the Independent Data Monitoring Committee (IDMC) and after reviewing unblinded data on June 16, 2017. The data indicated a higher rate of deaths, including fatal infections in the vadastuximab talirine-containing arm versus the control arm of the trial. Seattle Genetics is suspending patient enrollment and treatment in all of its vadastuximab talirine clinical trials.
    • 19 Jun 2017 Status changed from recruiting to discontinued, according to a Seattle Genetics media release.
    • 10 Jun 2017 Biomarkers information updated
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