Phase 1, Open-label Dose-escalation and Dose-expansion Study to Evaluate the Safety, Expansion, Persistence and Clinical Activity of a Single Dose of UCART123 (Allogeneic Engineered T-cells Expressing Anti-CD123 Chimeric Antigen Receptor), Administered in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Trial Profile

Phase 1, Open-label Dose-escalation and Dose-expansion Study to Evaluate the Safety, Expansion, Persistence and Clinical Activity of a Single Dose of UCART123 (Allogeneic Engineered T-cells Expressing Anti-CD123 Chimeric Antigen Receptor), Administered in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Suspended
Phase of Trial: Phase I

Latest Information Update: 18 Sep 2017

At a glance

  • Drugs UCART 123 (Primary)
  • Indications Haematological malignancies
  • Focus Adverse reactions
  • Acronyms ABC123
  • Sponsors Cellectis
  • Most Recent Events

    • 04 Sep 2017 According to a Cellectis media release, the US FDA has placed a clinical hold on both UCART123 ongoing Phase 1 studies, respectively in acute myeloid leukemia (AML) and in blastic plasmacytoid dendritic cell neoplasm (BPDCN).
    • 04 Sep 2017 Status changed from recruiting to suspended according to a Cellectis media release.
    • 17 Aug 2017 According to a Cellectis media release, first patient has been dosed.
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