Trial Profile

Neo-adjuvant Chemotherapy Combined With Stereotactic Body Radiotherapy to the Primary Tumour +/- Durvalumab, +/- Oleclumab in Luminal B Breast Cancer: a Phase ll Randomised Trial

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 13 May 2025

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At a glance

Drugs Durvalumab (Primary) ; Oleclumab (Primary) ; Cyclophosphamide; Doxorubicin; Paclitaxel
Indications Adenocarcinoma; Early breast cancer
Focus Adverse reactions; Therapeutic Use
Acronyms Neo-CheckRay

Most Recent Events

01 May 2025 Results evaluating preoperative immune-modulating stereotactic body radiation therapy (iSBRT) 8 Gy x 3 fractions in combination with chemotherapy with or without the anti PD-L1 durvalumab and the anti-CD73 oleclumab published in the Radiotherapy and Oncology.
20 Dec 2024 Planned primary completion date changed from 30 Sep 2024 to 30 May 2025.
13 Mar 2024 Planned End Date changed from 15 Jan 2026 to 30 Sep 2029.

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