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A Phase Ib Multicenter, Open-label Study to Evaluate the Safety and Tolerability of Trastuzumab Deruxtecan (T-DXd) and Immunotherapy Agents With and Without Chemotherapy Agents in First-line Treatment of Patients With Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) and Human Epidermal Growth Factor Receptor 2 (HER2) Overexpression (OE) (DESTINY-Lung03)

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Trial Profile

A Phase Ib Multicenter, Open-label Study to Evaluate the Safety and Tolerability of Trastuzumab Deruxtecan (T-DXd) and Immunotherapy Agents With and Without Chemotherapy Agents in First-line Treatment of Patients With Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) and Human Epidermal Growth Factor Receptor 2 (HER2) Overexpression (OE) (DESTINY-Lung03)

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 06 Oct 2025

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At a glance

  • Drugs Carboplatin (Primary) ; Cisplatin (Primary) ; Durvalumab (Primary) ; Pemetrexed (Primary) ; Trastuzumab-deruxtecan (Primary) ; Volrustomig (Primary)
  • Indications Non-small cell lung cancer
  • Focus Adverse reactions
  • Acronyms DL03
  • Sponsors AstraZeneca

Most Recent Events

  • 11 Aug 2025 Planned End Date changed from 23 Dec 2025 to 30 Jun 2027.
  • 11 Aug 2025 Planned primary completion date changed from 23 Dec 2025 to 30 Jun 2027.
  • 03 Sep 2024 According to an AstraZeneca media release, at WCLC 2024, an oral presentation will highlight efficacy and safety data from Part 1 of the DESTINY-Lung03 Phase Ib trial.

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