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A Phase Ib Multicenter, Open-label Study to Evaluate the Safety and Tolerability of Trastuzumab Deruxtecan (T-DXd) and Immunotherapy Agents With and Without Chemotherapy Agents in First-line Treatment of Patients With Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) and Human Epidermal Growth Factor Receptor 2 (HER2) Overexpression (OE) (DESTINY-Lung03)

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Trial Profile

A Phase Ib Multicenter, Open-label Study to Evaluate the Safety and Tolerability of Trastuzumab Deruxtecan (T-DXd) and Immunotherapy Agents With and Without Chemotherapy Agents in First-line Treatment of Patients With Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) and Human Epidermal Growth Factor Receptor 2 (HER2) Overexpression (OE) (DESTINY-Lung03)

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 19 Apr 2024

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At a glance

  • Drugs Carboplatin (Primary) ; Cisplatin (Primary) ; Durvalumab (Primary) ; Pemetrexed (Primary) ; Trastuzumab-deruxtecan (Primary) ; Volrustomig (Primary)
  • Indications Non-small cell lung cancer
  • Focus Adverse reactions
  • Acronyms DL03
  • Sponsors AstraZeneca

    • Most Recent Events

    • 24 Oct 2023 Trial design presented at the 48th European Society for Medical Oncology Congress
    • 24 Oct 2023 According to Trial design presented at the 48th European Society for Medical Oncology Congress, In part 1 enrollment has been completed. Part 2 of the trial was not initiated.
    • 24 Jul 2023 Drug Volrustomig has been added in this study, number of treatment arms changed to 6, Patient age criteria for inclusion changed to 18 year and older.
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