Drug Profile

Cabozantinib - Exelixis/Ipsen

Alternative Names: BMS-907351; CABOMETYX; Cabometyx; Cabozantinib s-malate; Cometriq; XL-184

Latest Information Update: 02 Sep 2026

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At a glance

Originator Exelixis
Developer Bristol-Myers Squibb; Centre Francois Baclesse; Dana-Farber Cancer Institute; Duke University Medical Center; Emory University; Exelixis; Ipsen; Massachusetts General Hospital; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); Roche; Swedish Orphan Biovitrum; Takeda; University of California at Irvine; University of Kentucky
Class Amides; Anilides; Antineoplastics; Cyclopropanes; Fluorine compounds; Quinolines; Small molecules
Mechanism of Action Axl receptor tyrosine kinase inhibitors; Fms-like tyrosine kinase 3 inhibitors; Proto-oncogene protein c-met inhibitors; Proto-oncogene protein c-ret inhibitors; TIE-2 receptor antagonists; TrkB receptor antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists; Vascular endothelial growth factor receptor-3 antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Neuroendocrine tumours; Liver cancer; Thyroid cancer
New Molecular Entity Yes

Marketed Liver cancer; Neuroendocrine tumours; Renal cell carcinoma; Thyroid cancer
Phase III Non-small cell lung cancer; Prostate cancer
Phase II Adenocarcinoma; Adrenocortical carcinoma; Bone metastases; Brain metastases; Breast cancer; Cervical cancer; Cholangiocarcinoma; Endometrial cancer; Ewing's sarcoma; Fallopian tube cancer; Gastrointestinal cancer; Head and neck cancer; Malignant melanoma; Merkel cell carcinoma; Osteosarcoma; Ovarian cancer; Peritoneal cancer; Phaeochromocytoma; Urogenital cancer; Uveal melanoma
Phase I/II Multiple myeloma; Solid tumours
No development reported Acute myeloid leukaemia; Cancer; Colorectal cancer
Discontinued Astrocytoma; Glioblastoma

31 Aug 2026 U.S. District Court for the District of Delaware dismisses lawsuit over Exelixis’ Cabozantinib, by MSN Laboratories for validity dispute over one of Exelixis’ patents covering low-impurity cabozantinib formulations (U.S. Patent No. 11,,
22 Jul 2026 Discontinued - Phase-I for Glioblastoma (Combination therapy) in USA (PO)
22 Jul 2026 Discontinued - Phase-II for Astrocytoma (Second-line therapy or greater) in Canada (PO)

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