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Tosedostat - CTI BioPharma

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Drug Profile

Tosedostat - CTI BioPharma

Alternative Names: CHR-2797

Latest Information Update: 28 Jun 2023

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At a glance

  • Originator Vernalis
  • Developer Azienda Ospedaliera Ospedali Riuniti Marche Nord; Cardiff University; CTI BioPharma
  • Class Amides; Antineoplastics; Benzene derivatives; Cyclopentanes; Esters; Hydroxamic acids; Small molecules
  • Mechanism of Action Aminopeptidase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Acute myeloid leukaemia; Myelodysplastic syndromes; Precursor cell lymphoblastic leukaemia-lymphoma; Solid tumours

Most Recent Events

  • 26 Jun 2023 CTI BioPharma has been acquired by Swedish Orphan Biovitrum
  • 21 Apr 2020 National Cancer Institute terminates phase I/II trial in Acute myeloid leukaemia and Myelodysplastic syndromes (In the elderly) in USA (NCT01636609)
  • 01 Jan 2020 Cardiff University completes a phase II/III trial in Myelodysplastic syndromes, Acute myeloid leukaemia and Precursor cell lymphoblastic leukaemia lymphoma (Combination therapy, In the elderly) in United Kingdom and Denmark (PO) (EudraCT2011-000749-19)

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