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Tepotinib - Merck

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Drug Profile

Tepotinib - Merck

Alternative Names: EMD-1214063; MSC-2156119; MSC-2156119J; TEPMETKO

Latest Information Update: 12 Dec 2025

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At a glance

  • Originator EMD Serono; Merck KGaA
  • Class Antineoplastics; Benzonitrile; Piperidines; Pyridazines; Pyrimidines; Small molecules
  • Mechanism of Action Proto-oncogene protein c-met inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase II Colorectal cancer; Liver cancer
  • Discontinued Solid tumours

Most Recent Events

  • 22 Oct 2025 Adverse events data from a phase II VISION trial in Non-small cell lung cancer presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2025 (AACR-NCI-EORTC-2025)
  • 22 Oct 2025 Updated efficacy and adverse events data from a phase II VISION trial in Non-small cell lung cancer presented at the International Conference on Molecular Targets and Cancer Therapeutics 2025 (AACR-NCI-EORTC-2025)
  • 06 Mar 2025 Launched for Non-small cell lung cancer (Metastatic disease, Late-stage disease) in Spain, Italy, Germany, France (PO) before March 2025

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