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Orismilast - UNION Therapeutics

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Drug Profile

Orismilast - UNION Therapeutics

Alternative Names: IBI-353; LEO32731; LP-0058; UNI-50001; UNI-50002

Latest Information Update: 28 Dec 2025

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At a glance

  • Originator LEO Pharma
  • Developer Innovent Biologics; LEO Pharma; UNION Therapeutics
  • Class Anti-inflammatories; Antipsoriatics; Benzodioxoles; Chlorinated hydrocarbons; Fluorinated hydrocarbons; Pyridines; Skin disorder therapies; Small molecules; Spiro compounds
  • Mechanism of Action Type 4 cyclic nucleotide phosphodiesterase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Atopic dermatitis; Hidradenitis suppurativa; Plaque psoriasis; Ulcerative colitis

Most Recent Events

  • 28 Dec 2025 No recent reports of development identified for phase-I development in Atopic-dermatitis(In volunteers) in China (PO, Tablet)
  • 28 Dec 2025 No recent reports of development identified for phase-I development in Hidradenitis suppurativa(In volunteers) in China (PO, Tablet)
  • 28 Dec 2025 No recent reports of development identified for phase-I development in Plaque-psoriasis(In volunteers) in China (PO, Tablet)

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