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Nitric oxide - Beyond Air

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Drug Profile

Nitric oxide - Beyond Air

Alternative Names: AIT-BRO; AIT-CF; AIT-COPD; AIT-NTM; AIT-NV; AIT-RSV; AIT-WH; gaseous NO - Beyond Air; gNO - Beyond Air; iNO - Beyond Air™; LV UNO; Nitric oxide inhaled; NOxAST; NOxBR; NOxCF; NOxCureBR; NOxCureCF; NOxPN; Ultra-High Concentration Nitric Oxide Therapy - Beyond Cancer; UNO therapy - Beyond Cancer; UNO-101

Latest Information Update: 09 Dec 2024

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At a glance

  • Originator University of British Columbia
  • Developer Beyond Air; Schneider Childrens Medical Center of Israel; University of British Columbia
  • Class Anti-infectives; Anti-inflammatories; Antiacnes; Antiandrogens; Antibacterials; Antibronchitics; Antifibrotics; Antifungals; Antihypertensives; Antineoplastics; Antituberculars; Antivirals; Cardiovascular therapies; Diagnostic agents; Foot disorder therapies; Free radicals; Nitrogen oxides; Non-opioid analgesics; Skin disorder therapies; Small molecules; Vascular disorder therapies; Vasodilators
  • Mechanism of Action Androgen receptor antagonists; Angiogenesis inducing agents; Cell death stimulants; Guanylate cyclase stimulants; Nitric oxide donors; Reactive oxygen species modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mycobacterial infections; Cystic fibrosis
  • New Molecular Entity No

Highest Development Phases

  • Phase III Bronchitis
  • Phase II Chronic obstructive pulmonary disease; COVID-19 pneumonia; Cystic fibrosis; Diabetic foot ulcer; Mycobacterial infections; Stroke
  • Phase I Solid tumours
  • No development reported COVID 2019 infections; Respiratory tract infections
  • Discontinued Asthma; Pneumonia

Most Recent Events

  • 03 Dec 2024 the Israeli Ministry of Health (IMOH) approves phase Ib clinical trial in Solid tumours (Combination therapy) in Israel
  • 03 Dec 2024 Beyond Air plans a phase Ib combination study in Solid tumours (Combination therapy; Unresectable/Inoperable; Second-line therapy or greater) in Israel in first quarter of 2025 (NCT05351502)
  • 11 Nov 2024 Pharmacodynamics data from the preclinical studies in Solid tumours released by Beyond Cancer

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