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Lemzoparlimab - NovaBridge Biosciences

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Drug Profile

Lemzoparlimab - NovaBridge Biosciences

Alternative Names: ABBV-IMAB-TJC4; Anti-CD47 antibody - NovaBridge Biosciences; TJ-011133; TJ-1133; TJC-4

Latest Information Update: 11 Nov 2025

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At a glance

  • Originator I-MAB Biopharma
  • Developer AbbVie; I-MAB Biopharma; NovaBridge Biosciences
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD47 antigen inhibitors; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Myelodysplastic syndromes
  • Discontinued Acute myeloid leukaemia; Gastric cancer; Head and neck cancer; Malignant melanoma; Multiple myeloma; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Ovarian cancer; Solid tumours

Most Recent Events

  • 30 Oct 2025 I-MAB Biopharma is now called NovaBridge Biosciences
  • 23 Apr 2025 I-MAB Biopharma terminates Phase-III clinical trials in Myelodysplastic syndromes (Combination therapy, First-line therapy) in China due to company Development strategy adjustment (IV) (NCT05709093)
  • 05 Jul 2024 Discontinued - Phase-I for Acute myeloid leukaemia (Combination therapy, First-line therapy) in Spain, United Kingdom, Japan, Italy, Germany, Australia, Israel, USA (IV)

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