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Aplitabart - IGM Biosciences

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Drug Profile

Aplitabart - IGM Biosciences

Alternative Names: IGM-8444

Latest Information Update: 28 Nov 2025

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At a glance

  • Originator IGM Biosciences
  • Class Antibodies; Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action TRAIL receptor 2 agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Non-Hodgkin's lymphoma
  • Suspended Acute myeloid leukaemia
  • No development reported Colorectal cancer; Solid tumours

Most Recent Events

  • 28 Nov 2025 No recent reports of development identified for phase-I development in Colorectal-cancer(Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Australia (IV)
  • 28 Nov 2025 No recent reports of development identified for phase-I development in Colorectal-cancer(Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in France (IV)
  • 28 Nov 2025 No recent reports of development identified for phase-I development in Colorectal-cancer(Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in South Korea (IV)

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