Drug Profile

Cibotercept - Keros Therapeutics

Alternative Names: KER-012; RKER 012

Latest Information Update: 14 Aug 2025

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At a glance

Originator Keros Therapeutics
Class Antihypertensives; Heart failure therapies; Immunoglobulin Fc fragments; Osteoporosis therapies; Recombinant fusion proteins
Mechanism of Action Transforming growth factor beta inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Discontinued Chronic heart failure; Osteogenesis imperfecta; Osteoporosis; Pulmonary arterial hypertension

Most Recent Events

06 Aug 2025 Discontinued - Phase-I for Osteoporosis (In volunteers) in Australia (SC)
06 Aug 2025 Discontinued - Phase-II for Chronic heart failure (unspecified route)
06 Aug 2025 Discontinued - Preclinical for Osteogenesis imperfecta in USA (SC)

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