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Research programme: antisense oligonucleotide therapeutics - Denali Therapeutics/Secarna Pharmaceuticals

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Drug Profile

Research programme: antisense oligonucleotide therapeutics - Denali Therapeutics/Secarna Pharmaceuticals

Alternative Names: OTV CH2; OTV LF3

Latest Information Update: 28 Feb 2026

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At a glance

  • Originator Denali Therapeutics Inc; Secarna Pharmaceuticals
  • Class Antidementias; Antiparkinsonians; Antisense oligonucleotides
  • Mechanism of Action Gene silencing
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Alzheimer's disease; CNS disorders; Neurodegenerative disorders; Parkinson's disease

Most Recent Events

  • 28 Feb 2026 No recent reports of development identified for preclinical development in CNS-disorders in Germany (IV)
  • 28 Feb 2026 No recent reports of development identified for preclinical development in CNS-disorders in USA (IV)
  • 28 Feb 2026 No recent reports of development identified for preclinical development in Neurodegenerative-disorders in Germany (IV)

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