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Zoldonrasib - REVOLUTION Medicines

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Drug Profile

Zoldonrasib - REVOLUTION Medicines

Alternative Names: RMC-9805

Latest Information Update: 17 Sep 2025

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At a glance

  • Originator REVOLUTION Medicines
  • Class Acetamides; Antineoplastics; Azabicyclo compounds; Aziridines; Cyclopentanes; Esters; Fluorinated hydrocarbons; Heterocyclic compounds with 4 or more rings; Indoles; Ketones; Methyl ethers; Morpholines; Piperazines; Pyridazines; Pyridines; Small molecules; Spiro compounds
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Adenocarcinoma; Non-small cell lung cancer

Most Recent Events

  • 17 Sep 2025 Chemical structure information added.
  • 06 Aug 2025 REVOLUTION Medicines plans one or more pivotal combination trials of zoldonrasib in 2026
  • 30 Jun 2025 Revolution Medicines and Summit Therapeutics agree to co-develop Zoldonrasib for Non-small cell lung cancer

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