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TNG 462

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Drug Profile

TNG 462

Alternative Names: TNG-462

Latest Information Update: 07 Jul 2025

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At a glance

  • Originator Tango Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action PRMT5 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer; Soft tissue sarcoma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Adenocarcinoma; Non-small cell lung cancer; Solid tumours
  • Preclinical Cancer

Most Recent Events

  • 31 May 2025 Phase-I/II clinical trials in Adenocarcinoma (Combination therapy, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT06922591)
  • 31 May 2025 Phase-I/II clinical trials in Non-small cell lung cancer (Combination therapy, Late-stage disease, Recurrent, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT06922591)
  • 12 May 2025 Tango Therapeutics plans a registrational trial for Pancreatic cancer (Monotherapy) in 2026

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