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NBI 1117570

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Drug Profile

NBI 1117570

Alternative Names: Dual M1/M4 agonist - Neurocrine Biosciences; Dual muscarinic M1/M4 agonist - Nxera Pharma; NBI-1117570; NBI-570

Latest Information Update: 22 Dec 2025

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At a glance

  • Originator Sosei Heptares
  • Developer Neurocrine Biosciences; Nxera Pharma
  • Class Antipsychotics; Small molecules
  • Mechanism of Action Muscarinic M1 receptor agonists; Muscarinic M4 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Schizophrenia

Most Recent Events

  • 22 Dec 2025 Phase-II clinical trials in Schizophrenia (PO), in December 2025 (NCT07288333)
  • 13 Oct 2025 NBI 1117570 is still in phase I trial for Schizophrenia (In volunteers) in the Netherlands (PO) (CTIS2023-508814-40-00)
  • 15 May 2025 Neurocrine Biosciences completes a phase I trial in Schizophrenia (In volunteers) in the Netherlands (PO) (CTIS2023-508814-40-00)

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