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An Open-Label, Dose-Escalation, Phase I/II Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of the MEK Inhibitor Trametinib (GSK1120212) in Subjects with Relapsed or Refractory Leukemias.

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An Open-Label, Dose-Escalation, Phase I/II Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of the MEK Inhibitor Trametinib (GSK1120212) in Subjects with Relapsed or Refractory Leukemias.

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 23 Aug 2023

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At a glance

  • Drugs Trametinib (Primary)
  • Indications Acute nonlymphocytic leukaemia; Chronic lymphocytic leukaemia; Chronic myeloid leukaemia; Chronic myelomonocytic leukaemia; Leukaemia; Myelodysplastic syndromes; Precursor cell lymphoblastic leukaemia-lymphoma
  • Focus Adverse reactions; Pharmacogenomic; Therapeutic Use
  • Sponsors GlaxoSmithKline; GSK

    • Most Recent Events

    • 26 Jul 2013 Status changed from recruiting to completed as reported by ClinicalTrials.gov.
    • 23 Aug 2012 Status changed from active, no longer recruiting to recruiting as reported by M.D. Anderson Cancer Center record.
    • 06 Jun 2012 Status changed from recruiting to active, no longer recruiting as reported by M.D. Anderson Cancer Center record.

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