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Phase II Randomised Trial of 5-azacitidine Versus 5-azacitidine in Combination With Vorinostat in Patients With Acute Myeloid Leukaemia or High Risk Myelodysplastic Syndromes Ineligible for Intensive Chemotherapy

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Trial Profile

Phase II Randomised Trial of 5-azacitidine Versus 5-azacitidine in Combination With Vorinostat in Patients With Acute Myeloid Leukaemia or High Risk Myelodysplastic Syndromes Ineligible for Intensive Chemotherapy

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 23 May 2022

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At a glance

  • Drugs Vorinostat (Primary) ; Azacitidine
  • Indications Acute myeloid leukaemia; Myelodysplastic syndromes
  • Focus Therapeutic Use
  • Acronyms RAvVA

    • Most Recent Events

    • 25 Jun 2017 Results assessing the molecular predictors of response to azacitidine therapy, presented at the 22nd Congress of the European Haematology Association
    • 19 Jun 2017 According to a Celgene Corporation media release, data from this trial will be presented at the 22nd European Hematology Association annual meeting 2017.
    • 06 Dec 2016 Primary endpoint (Phase II - Overall Survival) has not been met, according to the results presented at the 58th Annual Meeting and Exposition of the American Society of Hematology

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