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A Phase I Trial of MEK Inhibitor Trametinib in Combination With Neoadjuvant 5-Fluorouracil Chemoradiation in the Treatment of KRAS, BRAF, and NRAS-MUTANT Rectal Cancers

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Trial Profile

A Phase I Trial of MEK Inhibitor Trametinib in Combination With Neoadjuvant 5-Fluorouracil Chemoradiation in the Treatment of KRAS, BRAF, and NRAS-MUTANT Rectal Cancers

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 20 Sep 2023

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At a glance

  • Drugs Trametinib (Primary) ; Fluorouracil; Folinic acid; Oxaliplatin
  • Indications Adenocarcinoma; Rectal cancer
  • Focus Adverse reactions
  • Most Recent Events

    • 14 Sep 2023 Status changed from active, no longer recruiting to completed.
    • 24 Nov 2020 Planned primary completion date changed from 31 Dec 2017 to 31 Dec 2021.
    • 06 Apr 2020 Results published in the Clinical Cancer Research

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