Trial Profile

A Dual Phase 1/2, Investigator Initiated Study to Determine the Maximum Tolerated Dose, Safety, and Efficacy of 186Rhenium Nanoliposomes (186RNL) in Recurrent Glioma (CTRC 12-02)

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 16 Dec 2025

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At a glance

Drugs Rhenium (186Re) obisbemeda (Primary)
Indications Astrocytoma; Diffuse intrinsic pontine glioma; Ependymoma; Glioblastoma; Glioma
Focus Adverse reactions; First in man; Registrational; Therapeutic Use
Acronyms ReSPECT; ReSPECT-GBM; ReSPECT-TM
Sponsors Plus Therapeutics

04 Dec 2025 According to the Plus Therapeutics Media Release, data from this study were presented at the World Federation of Neuro-Oncology Societies/Society for Neuro-Oncology (WFNOS/SNO) Annual Meeting, November 19-23, 2025 in Honolulu, Hawaii.
04 Dec 2025 According to the Plus Therapeutics Media Release, ongoing Phase 2 study has enrolled 24 of planned 34 patients as of data cutoff.
26 Mar 2025 Planned End Date changed from 1 Jan 2025 to 1 Dec 2025.

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