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A Phase 1/2, Multicenter, Open-label, and Dose-escalation Study of ACP-196 in Subjects With Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia

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Trial Profile

A Phase 1/2, Multicenter, Open-label, and Dose-escalation Study of ACP-196 in Subjects With Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 14 Jan 2025

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At a glance

  • Drugs Acalabrutinib (Primary)
  • Indications B-cell prolymphocytic leukaemia; Chronic lymphocytic leukaemia; Lymphoid leukaemia; Richter's syndrome; T-cell prolymphocytic leukaemia
  • Focus Adverse reactions; First in man; Pharmacokinetics
  • Sponsors Acerta Pharma

Most Recent Events

  • 01 Jan 2025 Results published in the Hematological Oncology
  • 29 Nov 2023 According to an AstraZeneca media release, analysis of 5 studies (CL-001, CL-003, CL-006, CL-007 & CL-309) showing acceptable safety outcomes based on rates of nonfatal and fatal ventricular arrhythmias and sudden death in patients with CLL will be presented at 65th American Society of Hematology (ASH) Annual Meeting and Exposition in San Diego, CA, 9 to 12 December 2023.
  • 14 Jul 2023 Planned End Date changed from 15 Jul 2026 to 6 Sep 2027.

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