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An Open-Label, Multi-Center Controlled Clinical Trial of Eculizumab in Adolescent Patients With Plasma Therapy-Resistant Atypical Hemolytic Uremic Syndrome (AHUS)

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Trial Profile

An Open-Label, Multi-Center Controlled Clinical Trial of Eculizumab in Adolescent Patients With Plasma Therapy-Resistant Atypical Hemolytic Uremic Syndrome (AHUS)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 03 Nov 2023

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At a glance

  • Drugs Eculizumab (Primary)
  • Indications Atypical Haemolytic Uraemic Syndrome
  • Focus Therapeutic Use
  • Sponsors Alexion Pharmaceuticals

    • Most Recent Events

    • 12 Dec 2021 Results of patient-level data from four eculizumab clinical trials (C08-002A/B (NCT00844545/NCT00844844), C10-003 (NCT01193348), and C10-004 (NCT01194973) were available for pooling and comparison with data from two ravulizumab trials (ALXN-aHUS-311 (NCT02949128) and ALXN-aHUS-312 (NCT03131219) assessing the effectiveness of ravulizumab and eculizumab for the treatment of aHUS, accounting for observed differences between clinical studies, published in the Clinical Nephrology.
    • 19 Jul 2019 This trial has been completed in United Kingdom, according to European Clinical Trials Database.
    • 11 Jun 2014 Status changed from active, no longer recruiting to completed as reported by ClinicalTrials.gov.

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