Trial Profile

An Open Label, Two-Part, Phase Ib/II Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of the MEK Inhibitor Trametinib and the BCL2-Family Inhibitor Navitoclax (ABT-263) in Combination in Subjects With KRAS or NRAS Mutation-Positive Advanced Solid Tumors

Status: Active, no longer recruiting

Phase of Trial: Phase I/II

Latest Information Update: 26 Apr 2025

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At a glance

Drugs Navitoclax (Primary) ; Trametinib (Primary)
Indications Colorectal cancer; Gynaecological cancer; Non-small cell lung cancer; Pancreatic cancer; Solid tumours
Focus Adverse reactions; Therapeutic Use

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