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A Randomized Open-Label Phase III Trial of MK-3475 versus Platinum based Chemotherapy in 1L Subjects with PD-L1 Strong Metastatic Non-Small Cell Lung Cancer

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Trial Profile

A Randomized Open-Label Phase III Trial of MK-3475 versus Platinum based Chemotherapy in 1L Subjects with PD-L1 Strong Metastatic Non-Small Cell Lung Cancer

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 19 Nov 2025

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At a glance

  • Drugs Pembrolizumab (Primary) ; Carboplatin; Cisplatin; Gemcitabine; Paclitaxel; Pemetrexed
  • Indications Non-small cell lung cancer; Squamous cell cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms KEYNOTE-024
  • Sponsors Merck Sharp & Dohme

Most Recent Events

  • 20 Oct 2025 According to the Merck and Co Media Release, the 8-year analyses of KEYNOTE-024 and -042, were presented during a poster session at the European Society for Medical Oncology (ESMO) Congress 2025.
  • 20 Oct 2025 Results presented in the Merck and Co Media Release.
  • 09 Nov 2022 Results evaluating the cost-effectiveness of cemiplimab versus pembrolizumab by deriving OS and PFS data from EMPOWER-Lung 1 (cemiplimab) and KEYNOTE-024 (pembrolizumab), presented at the 25th Annual European Congress of the International Society for Pharmacoeconomics and Outcomes Research

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