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A Phase 3, Double-Blind, Placebo Controlled Multicenter Study to Determine the Efficacy and Safety of Luspatercept (ACE-536) in Adults With Transfusion Dependent Beta (B)-Thalassemia

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Trial Profile

A Phase 3, Double-Blind, Placebo Controlled Multicenter Study to Determine the Efficacy and Safety of Luspatercept (ACE-536) in Adults With Transfusion Dependent Beta (B)-Thalassemia

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 26 Nov 2024

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At a glance

  • Drugs Luspatercept (Primary)
  • Indications Beta-thalassaemia
  • Focus Registrational; Therapeutic Use
  • Acronyms BELIEVE
  • Sponsors Celgene Corporation

    • Most Recent Events

    • 19 Nov 2024 According to a Bristol Myers Squibb media release, results from this trial will be presented at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, to be held from December 7 to 10 in San Diego, California.
    • 01 Feb 2024 Results assessing effect of Luspatercept in stimulates erythropoiesis, increases iron utilization, and redistributes body iron in transfusion-dependent thalassemia published in the American Journal of Hematology
    • 12 Dec 2023 Results of post hoc Subgroup Analysis (n=52) assessing Efficacy and Safety of Luspatercept in Patients with HbE/beta Thalassemia presented at the 65th American Society of Hematology Annual Meeting and Exposition

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