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A Phase III Multicenter, Double-Blind, Randomized, Active Comparator-Controlled Clinical Trial to Evaluate the Safety and Efficacy of MK-1439A Once-Daily Versus ATRIPLA Once-Daily in Treatment-Naive HIV-1 Infected Subjects

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Trial Profile

A Phase III Multicenter, Double-Blind, Randomized, Active Comparator-Controlled Clinical Trial to Evaluate the Safety and Efficacy of MK-1439A Once-Daily Versus ATRIPLA Once-Daily in Treatment-Naive HIV-1 Infected Subjects

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 11 Oct 2024

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At a glance

  • Drugs Doravirine/lamivudine/tenofovir disoproxil fumarate (Primary) ; Efavirenz/emtricitabine/tenofovir-disoproxil-fumarate
  • Indications HIV-1 infections
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms DRIVE-AHEAD
  • Sponsors Merck Sharp & Dohme Corp.

Most Recent Events

  • 22 Sep 2023 Status changed from active, no longer recruiting to completed.
  • 26 Oct 2022 Results (of three phase 3 studies DRIVE-FORWARD, DRIVE- AHEAD and DRIVE-SHIFT) assessing Factors associated with weight loss or stable weight after continuing or switching to a doravirine-based regimen presented at the 16th International Congress on Drug Therapy and HIV Infection
  • 26 Oct 2022 Results (of open-label extensions of the two studies DRIVE-AHEAD and DRIVE-FORWARD ) Resolution of neuropsychiatric adverse events after switching to a doravirine-based regimen presented at the 16th International Congress on Drug Therapy and HIV Infection

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