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Evaluation of the Effect of 0.4 mg Nitroglycerin Spray After Pretreatment With Multiple Once Daily Oral Doses of 2.5 mg, 5 mg and 10 mg Vericiguat (BAY 1021189) Each Given Over 14 ± 3 Days on Safety, Tolerability and Blood Pressure in a Multi-center, Randomized, Placebo-controlled, Double-blind Group Comparison Study in Stable Coronary Artery Disease (CAD) Patients Aged 30 to 80 Years

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Trial Profile

Evaluation of the Effect of 0.4 mg Nitroglycerin Spray After Pretreatment With Multiple Once Daily Oral Doses of 2.5 mg, 5 mg and 10 mg Vericiguat (BAY 1021189) Each Given Over 14 ± 3 Days on Safety, Tolerability and Blood Pressure in a Multi-center, Randomized, Placebo-controlled, Double-blind Group Comparison Study in Stable Coronary Artery Disease (CAD) Patients Aged 30 to 80 Years

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 12 May 2022

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At a glance

  • Drugs Vericiguat (Primary) ; Nitroglycerin
  • Indications Angina pectoris; Coronary artery disease
  • Focus Adverse reactions
  • Acronyms VENICE
  • Sponsors Bayer

Most Recent Events

  • 08 Mar 2022 Results evaluating safety, tolerability, and the pharmacodynamic interaction between vericiguat and nitroglycerin, co-administered in patients with chronic coronary syndromes, published in the Clinical Pharmacology and Therapeutics
  • 15 Nov 2017 Results assessing safety presented at the 90th Annual Scientific Sessions of the American Heart Association.
  • 23 Aug 2016 Status changed from recruiting to completed.

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