Trial Profile

NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 21 May 2025

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At a glance

Drugs Ensartinib (Primary) ; Erdafitinib (Primary) ; Larotrectinib (Primary) ; Larotrectinib (Primary) ; Olaparib (Primary) ; Palbociclib (Primary) ; Samotolisib (Primary) ; Selpercatinib (Primary) ; Selumetinib (Primary) ; Tazemetostat (Primary) ; Tipifarnib (Primary) ; Tipifarnib (Primary) ; Ulixertinib (Primary) ; Vemurafenib (Primary)
Indications CNS cancer; Ependymoma; Ewing's sarcoma; Germ cell and embryonal neoplasms; Germ cell cancer; Glioma; Hepatoblastoma; Langerhans cell histiocytosis; Lymphoma; Neuroblastoma; Non-Hodgkin's lymphoma; Osteosarcoma; Rhabdomyosarcoma; Soft tissue sarcoma; Solid tumours; Wilms' tumour
Focus Therapeutic Use
Acronyms Pediatric MATCH

13 May 2025 Planned End Date changed from 30 Jun 2025 to 9 May 2026.
08 Jan 2025 Planned End Date changed from 30 Sep 2027 to 30 Jun 2025.
08 Jan 2025 Planned primary completion date changed from 30 Sep 2027 to 30 Jun 2025.

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