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An Open-Label, Dose Escalation and Dose Expansion Trial Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered CA-4948 in Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma

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Trial Profile

An Open-Label, Dose Escalation and Dose Expansion Trial Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered CA-4948 in Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 13 Aug 2026

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At a glance

  • Drugs Emavusertib (Primary) ; Ibrutinib (Primary)
  • Indications Acute myeloid leukaemia; B-cell lymphoma; Chronic lymphocytic leukaemia; CNS cancer; Diffuse large B cell lymphoma; Haematological malignancies; Lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
  • Focus Adverse reactions; First in man; Registrational; Therapeutic Use
  • Acronyms TakeAim Lymphoma
  • Sponsors Curis

Most Recent Events

  • 22 Jul 2026 Results presented in av a Curis media release.
  • 22 Jul 2026 According to Curis media release, the company announced that it will host a webcast on Wednesday, July 22 at 8:30 a.m. ET to discuss positive updated clinical data in the TakeAim Lymphoma study.
  • 22 Jul 2026 According to a Curis media release, Part B is an ongoing single-arm study in BTKi-experienced patients. Part C is an ongoing randomized study in BTKi-naive patients.

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