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An Open-Label, Dose Escalation and Dose Expansion Trial Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered CA-4948 in Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma

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Trial Profile

An Open-Label, Dose Escalation and Dose Expansion Trial Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered CA-4948 in Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 29 Sep 2025

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At a glance

  • Drugs Emavusertib (Primary) ; Ibrutinib (Primary)
  • Indications Acute myeloid leukaemia; B-cell lymphoma; Chronic lymphocytic leukaemia; CNS cancer; Diffuse large B cell lymphoma; Haematological malignancies; Lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms TakeAim Lymphoma
  • Sponsors Curis

Most Recent Events

  • 05 Aug 2025 According to a Curis media release, company looks forward to providing updated data later this year
  • 05 Aug 2025 According to a Curis media release, this study continued to enroll PCNSL patients in both Part B (BTKi-experienced patients) and Part C (BTKi-naive patients) to enable accelerated approval filings in the US and EU.
  • 06 May 2025 According to a Curis media release, Company expect to provide additional data for both BTK-naive and BTK-experienced patients from the TakeAim Lymphoma study at ASH later in 2025.

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