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A Phase I/II Open Label Study of the Safety and Efficacy of Apatinib Administered to Patients With Advanced Malignancies to Improve Sensitivity to Pembrolizumab in the Second- or Later-line Setting (APPEASE)

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A Phase I/II Open Label Study of the Safety and Efficacy of Apatinib Administered to Patients With Advanced Malignancies to Improve Sensitivity to Pembrolizumab in the Second- or Later-line Setting (APPEASE)

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 05 Nov 2021

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At a glance

  • Drugs Pembrolizumab (Primary) ; Rivoceranib (Primary)
  • Indications Adenocarcinoma; Carcinoma; Colorectal cancer; Gastric cancer; Oesophageal cancer; Solid tumours; Urogenital cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms APPEASE

    • Most Recent Events

    • 13 Jul 2020 Status changed from active, no longer recruiting to discontinued.
    • 07 Jul 2020 Planned End Date changed from 1 Jun 2023 to 1 Aug 2020.
    • 24 Oct 2019 Status changed from recruiting to active, no longer recruiting.

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