Trial Profile

A Long-Term Safety Extension Study of Mavacamten (MYK-461) in Adults With Hypertrophic Cardiomyopathy Who Have Completed the MAVERICK-HCM (MYK-461-006) or EXPLORER-HCM (MYK-461-005) Trials (MAVA-LTE)

Status: Active, no longer recruiting

Phase of Trial: Phase II/III

Latest Information Update: 24 Jun 2025

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At a glance

Drugs Mavacamten (Primary)
Indications Hypertrophic cardiomyopathy
Focus Adverse reactions; Pharmacodynamics; Registrational; Therapeutic Use
Acronyms MAVA-LTE
Sponsors Bristol-Myers Squibb; MyoKardia

Most Recent Events

17 Jun 2025 Planned End Date changed from 15 Mar 2030 to 16 Jan 2026.
17 Jun 2025 Planned primary completion date changed from 15 Mar 2030 to 16 Jan 2026.
01 Sep 2024 According to a Bristol-Myers Squibb media release, data from this trial presented at the European Society of Cardiology (ESC) Congress

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