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A Phase II Study of IL-1 Receptor Antagonist Anakinra to Prevent Severe Neurotoxicity and Cytokine Release Syndrome in Patients Receiving CD19-Specific Chimeric Antigen Receptor (CAR) T Cells

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Trial Profile

A Phase II Study of IL-1 Receptor Antagonist Anakinra to Prevent Severe Neurotoxicity and Cytokine Release Syndrome in Patients Receiving CD19-Specific Chimeric Antigen Receptor (CAR) T Cells

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 06 Nov 2024

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At a glance

  • Drugs Anakinra (Primary)
  • Indications Cytokine release syndrome; Neurotoxicity syndrome
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 04 Nov 2024 Planned End Date changed from 1 Oct 2024 to 1 Oct 2025.
  • 04 Nov 2024 Planned primary completion date changed from 1 Oct 2024 to 1 Oct 2025.
  • 12 Dec 2023 Results (n-31, cohort 2) presented at the 65th American Society of Hematology Annual Meeting and Exposition

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