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A Randomized, Double-blind, Dose-ranging, Placebo-controlled, Phase 2a Evaluation of the Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Participants With Primary Sclerosing Cholangitis (PSC) and Suspected Liver Fibrosis (INTEGRIS-PSC)

Trial Profile

A Randomized, Double-blind, Dose-ranging, Placebo-controlled, Phase 2a Evaluation of the Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Participants With Primary Sclerosing Cholangitis (PSC) and Suspected Liver Fibrosis (INTEGRIS-PSC)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 03 Jun 2025

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At a glance

  • Drugs Bexotegrast (Primary)
  • Indications Hepatic fibrosis; Primary sclerosing cholangitis
  • Focus Adverse reactions
  • Acronyms INTEGRIS-PSC
  • Sponsors Pliant Therapeutics

Most Recent Events

  • 18 Nov 2024 According to a Pliant Therapeutics media release, company announced the presentation of clinical data of this study at The Liver Meeting 2024 of the American Association for the Study of Liver Diseases (AASLD) being held in San Diego, California.
  • 17 Oct 2024 According to a Pliant Therapeutics media release, 24 week result from the INTEGRIS-PSC Phase 2a trial of bexotegrast will be presented at The Liver Meeting 2024 of the American Association for the Study of Liver Diseases (AASLD), in San Diego, California November 15-19.
  • 10 Sep 2024 According to a Pliant Therapeutics media release, integrated safety summary of bexotegrast from the INTEGRIS-IPF and INTEGRIS-PSC were presented at the European Respiratory Society (ERS) International Congress 2024 taking place in Vienna, Austria September 7-11, 2024.

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