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A Phase 2 Study to Evaluate CD19-Specific Chimeric Antigen Receptor (CAR)-T Cells Combined With Acalabrutinib for Patients With Relapsed or Refractory Mantle Cell Lymphoma (MCL)

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Trial Profile

A Phase 2 Study to Evaluate CD19-Specific Chimeric Antigen Receptor (CAR)-T Cells Combined With Acalabrutinib for Patients With Relapsed or Refractory Mantle Cell Lymphoma (MCL)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 10 Dec 2025

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At a glance

  • Drugs Acalabrutinib (Primary) ; CAR-T cell therapies (Primary)
  • Indications Mantle-cell lymphoma
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 26 Nov 2025 Planned End Date changed from 2 Sep 2025 to 2 Sep 2026.
  • 26 Nov 2025 Planned primary completion date changed from 2 Sep 2025 to 2 Sep 2026.
  • 19 Dec 2024 Planned End Date changed from 2 Dec 2024 to 2 Sep 2025.

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