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A Phase I, Open-label, Randomized, Single-dose Study of Acalabrutinib in Healthy Subjects to Evaluate the Effect of Proton-pump Inhibitor (Rabeprazole) on Acalabrutinib Capsule When Administered Orally With COCA-COLA

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A Phase I, Open-label, Randomized, Single-dose Study of Acalabrutinib in Healthy Subjects to Evaluate the Effect of Proton-pump Inhibitor (Rabeprazole) on Acalabrutinib Capsule When Administered Orally With COCA-COLA

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 14 May 2021

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At a glance

  • Drugs Acalabrutinib (Primary) ; Rabeprazole
  • Indications B-cell lymphoma; B-cell prolymphocytic leukaemia; Bladder cancer; Chronic lymphocytic leukaemia; COVID 2019 infections; Diffuse large B cell lymphoma; Follicular lymphoma; Glioblastoma; Head and neck cancer; Infections; Mantle-cell lymphoma; Multiple myeloma; Non-Hodgkin's lymphoma; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Rheumatoid arthritis; Richter's syndrome; Waldenstrom's macroglobulinaemia
  • Focus Pharmacokinetics
  • Sponsors AstraZeneca

    • Most Recent Events

    • 29 Oct 2020 Status changed from recruiting to completed.
    • 04 Aug 2020 New trial record
    • 03 Aug 2020 Planned primary completion date changed from 20 Aug 2020 to 28 Aug 2020.

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