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A Phase 1, Dose Escalation, Safety and Tolerability Study of NX-2127, a Bruton's Tyrosine Kinase (BTK) Degrader, in Adults With Relapsed/Refractory B-cell Malignancies

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Trial Profile

A Phase 1, Dose Escalation, Safety and Tolerability Study of NX-2127, a Bruton's Tyrosine Kinase (BTK) Degrader, in Adults With Relapsed/Refractory B-cell Malignancies

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 15 Oct 2024

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At a glance

  • Drugs NX-2127 (Primary)
  • Indications B-cell leukaemia; B-cell lymphoma; Chronic lymphocytic leukaemia; CNS cancer; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Waldenstrom's macroglobulinaemia
  • Focus Adverse reactions; First in man; Proof of concept; Therapeutic Use
  • Sponsors Nurix

    • Most Recent Events

    • 11 Oct 2024 According to a Nurix media release, clinical updates on this trial are anticipated in 2025.
    • 11 Sep 2024 Planned number of patients changed from 160 to 248.
    • 26 Jul 2024 Planned End Date changed from 1 Dec 2025 to 1 Dec 2026.

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