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A Randomized, Placebo-controlled, Parallel Phase 2a Dose-ranging Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors

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Trial Profile

A Randomized, Placebo-controlled, Parallel Phase 2a Dose-ranging Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 06 Mar 2026

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At a glance

  • Drugs Aprepitant (Primary)
  • Indications Acneiform eruptions; Exanthema; Pruritus; Skin disorders
  • Focus First in man; Pharmacokinetics; Therapeutic Use
  • Acronyms CLEER; CLEER-001
  • Sponsors Hoth Therapeutics

Most Recent Events

  • 24 Feb 2026 Primary endpoint (Acneiform Rash Investigators Global Assessment Scale [ARIGA ]) has been met, according to a Hoth Therapeutics media release.
  • 24 Feb 2026 Results presented in the Hoth Therapeutics Media Release.
  • 24 Feb 2026 According to a Hoth Therapeutics media release, company announced a significant expansion of its CLEER-001 Phase 2a clinical trial with the addition of Regis Clinical Research as a new enrolling site located in Miami, Florid since the patient demand outpaces capacity at existing sites.

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