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A Randomized, Placebo-controlled, Parallel Phase 2a Dose-ranging Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors

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Trial Profile

A Randomized, Placebo-controlled, Parallel Phase 2a Dose-ranging Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 11 Jun 2025

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At a glance

  • Drugs Aprepitant (Primary)
  • Indications Acneiform eruptions; Exanthema; Pruritus; Skin disorders
  • Focus First in man; Pharmacokinetics; Therapeutic Use
  • Acronyms CLEER; CLEER-001
  • Sponsors Hoth Therapeutics

Most Recent Events

  • 05 Jun 2025 According to a Hoth Therapeutics media release, company will present the interim results from this study at a Key Opinion Leader (KOL) event showcasing HT-001 including the preliminary data showing safety and efficacy in the open-label cohort of this trial.
  • 15 Apr 2025 Results containing interim data from the open-label portion of its Phase 2a clinical trial presented in the Hoth Therapeutics Media Release.
  • 07 Jan 2025 According to a Hoth Therapeutics media release, company eagerly awaited full results from this trial as patient enrollment continues.

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