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An open-label study to investigate the safety and pharmacokinetics of multiple ascending doses of antisense oligonucleotide STK-001 in children and adolescents with Dravet syndrome

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Trial Profile

An open-label study to investigate the safety and pharmacokinetics of multiple ascending doses of antisense oligonucleotide STK-001 in children and adolescents with Dravet syndrome

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 09 Dec 2024

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At a glance

  • Drugs Zorevunersen (Primary)
  • Indications Dravet syndrome
  • Focus Adverse reactions; Pharmacokinetics
  • Acronyms ADMIRAL; STK-001-DS-102 (ADMIRAL)
  • Sponsors Stoke Therapeutics

    • Most Recent Events

    • 02 Dec 2024 According to a Stoke Therapeutics media release, new data from this trial will be presented at the American Epilepsy Society (AES) 2024 Annual Meeting, taking place December 6 - 10, in Los Angeles, California. New data will include 9 patients who received two or three initial doses of 70mg of zorevunersen in a Phase 1/2 study and then continued treatment in an open-label extension (OLE) study, where they received at least two doses of 45mg.
    • 10 Sep 2024 Results published in a Stoke Therapeutics media release
    • 10 Sep 2024 According to a Stoke Therapeutics media release, new data from this trial presented at presentations at the 15th European Epilepsy Congress (EEC) for Dravet syndrome.

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