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Phase 1/2a clinical trial to determine the maximum tolerated dose, safety, tolerability and early efficacy of rhenium (186Re) obisbemeda in supratentorial recurrent or progressive pediatric ependymoma and high-grade glioma (HGG)

Trial Profile

Phase 1/2a clinical trial to determine the maximum tolerated dose, safety, tolerability and early efficacy of rhenium (186Re) obisbemeda in supratentorial recurrent or progressive pediatric ependymoma and high-grade glioma (HGG)

Status: Planning
Phase of Trial: Phase I/II

Latest Information Update: 02 Jul 2025

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At a glance

  • Drugs Rhenium (186Re) obisbemeda (Primary)
  • Indications Brain cancer; Ependymoma; Glioblastoma; Glioma
  • Focus Therapeutic Use
  • Acronyms ReSPECT-PBC
  • Sponsors Plus Therapeutics

Most Recent Events

  • 25 Jun 2025 According to a Plus Therapeutics media release, Dr. Ashley S. Plant is a Principal Investigator for the trial.
  • 25 Jun 2025 According to a Plus Therapeutics media release, company announced that the trial is funded by a $3.0M research grant from the U.S. Department of Defense.
  • 25 Jun 2025 According to a Plus Therapeutics media release, company announced that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application.

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