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A Phase 1/2 Study of LY3537982 in Patients With KRAS G12C-Mutant Advanced Solid Tumors

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Trial Profile

A Phase 1/2 Study of LY3537982 in Patients With KRAS G12C-Mutant Advanced Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 13 Nov 2025

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At a glance

  • Drugs Abemaciclib (Primary) ; Carboplatin (Primary) ; Cetuximab (Primary) ; Cisplatin (Primary) ; Olomorasib (Primary) ; Pembrolizumab (Primary) ; Pemetrexed (Primary)
  • Indications Adenoid cystic carcinoma; Brain metastases; Carcinoma; Cholangiocarcinoma; Chondrosarcoma; Colorectal cancer; Endometrial cancer; Head and neck cancer; Intestinal cancer; Malignant melanoma; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Solid tumours; Squamous cell cancer; Urogenital cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms KRAS G12C
  • Sponsors Eli Lilly and Company

Most Recent Events

  • 13 Oct 2025 According to an Eli Lilly and Company media release, data from this study will be presented at the European Society for Medical Oncology (ESMO) Annual Meeting, taking place October 17-21 in Berlin, Germany.
  • 04 Sep 2025 According to an Eli Lilly and Company media release, the company announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to olomorasib, in combination with KEYTRUDA (pembrolizumab), for the first-line treatment of patients with unresectable advanced or metastatic non-small cell lung cancer (NSCLC). The designation is based on results of LOXO-RAS-20001 trial and dose optimization portion of the Phase 3 SUNRAY-01 trial.
  • 25 Jun 2025 Planned number of patients changed from 540 to 680.

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